BackgroundThe emergence of artificial intelligence (AI) in medicine has prompted the development of numerous ethical guidelines, while the involvement of patients in the creation of these documents lags behind. As part of the European PROFID project we explore patient perspectives on the ethical implications of AI in care for patients at increased risk of sudden cardiac death (SCD).AimExplore perspectives of patients on the ethical use of AI, particularly in clinical decision-making regarding the implantation of an implantable cardioverter-defibrillator (ICD).MethodsSemi-structured, future scenario-based (...) interviews were conducted among patients who had either an ICD and/or a heart condition with increased risk of SCD in Germany (n = 9) and the Netherlands (n = 15). We used the principles of the European Commission’s Ethics Guidelines for Trustworthy AI to structure the interviews.ResultsSix themes arose from the interviews: the ability of AI to rectify human doctors’ limitations; the objectivity of data; whether AI can serve as second opinion; AI explainability and patient trust; the importance of the ‘human touch’; and the personalization of care. Overall, our results reveal a strong desire among patients for more personalized and patient-centered care in the context of ICD implantation. Participants in our study express significant concerns about the further loss of the ‘human touch’ in healthcare when AI is introduced in clinical settings. They believe that this aspect of care is currently inadequately recognized in clinical practice. Participants attribute to doctors the responsibility of evaluating AI recommendations for clinical relevance and aligning them with patients’ individual contexts and values, in consultation with the patient.ConclusionThe ‘human touch’ patients exclusively ascribe to human medical practitioners extends beyond sympathy and kindness, and has clinical relevance in medical decision-making. Because this cannot be replaced by AI, we suggest that normative research into the ‘right to a human doctor’ is needed. Furthermore, policies on patient-centered AI integration in clinical practice should encompass the ethics of everyday practice rather than only principle-based ethics. We suggest that an empirical ethics approach grounded in ethnographic research is exceptionally well-suited to pave the way forward. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Journal Name: Cognitive Linguistics Issue: Ahead of print.

This article endorses with substantial modifications M. Bernal's claim that the Greeks based Memnon on Ammenemes II of Egypt. An Egyptian origin for Memnon appears likely from Zeus' weighing of his fate against Achilles' in the Aethiopis, which is similar to an early spell of the Book of the Dead; from his Amazonian ally, who resembles the Nile-god, clad in a girdle with a single breast; and from his apotheosis, which is unlike Homer's usual view that the soul is witless (...) in death, yet is reminiscent of the soteriological Osiris-cult, which was known to the Mycenaeans. Bernal's view that Memnon was specifically Ammenemes, however, rests on one word in Strabo, judged by editors to be a scribal error. Cases for two other proposed models, Khumben-numena I of Elam and Sethos I of Egypt, are too complex and fragile to accept. Since at least the first century, the Greeks themselves linked Memnon to Amenhotep III of Egypt, calling a portrait-colossus of that pharaoh "Memnon." This identification was based, I argue, on the fact that the statue faces sunrise on the winter solstice and so was linked to the dawn. Amenhotep's name is too unlike Memnon's to have attracted to him a preexisting Greek figure, but, as P. Gilbert proposed, Amenhotep may have been the basis for that figure, for archaeological evidence shows his contact with the Aegean. Like Memnon, Amenhotep formed military pacts with eastern kings, was son of a solar deity, and was exceptionally handsome. Moreover, his father's name was Tuthmosis . In short, Bernal argues well that epic based Memnon on a real person, rightly seeks him in Egypt, but fails to rule out Amenhotep. (shrink)

The Primacy of God, the notion of justice toward God is seldom considered and often foreign. Far more discussed is how God might either undermine or motivate social justice. The Primacy of God by R. Jared Staudt offers an important intervention. With the aid of St. Thomas Aquinas, Staudt argues that it is vital for both contemporary society and contemporary Catholic theology to return to the traditional view of God as the one to whom all human and social action must (...) be ordered and to recover the virtue of religion as the virtue which orders all other virtues to God. Not only does Staudt helpfully remind readers of the ancient philosophical and biblical notion of worship as a dictate of the natural law, he also illuminates the way in which Christian liturgy, as an enactment of Christ's high priesthood, is the great fulfillment of natural and biblical worship. Accordingly, Staudt secures religion as essential for the virtue of love. This brings Staudt to criticize modern theologians like Karl Barth, who claimed that religion is inherently idolatrous, as well as Karl Rahner, who claimed that love of neighbor is the highest moral act. Staudt also considers the question of religious truth in light of the plurality of religions, soliciting the assistance of Hans Urs von Balthasar and Joseph Ratzinger, as well as the way in which religion relates to the development of culture, engaging the great Catholic social historian Christopher Dawson. The Primacy of God is a much-needed work that ought to set the agenda for Catholic theology in the twenty-first century. (shrink)

1. Tasan ŭi kyŏnghak kwa yŏkhak -- 2. Tasanhak chʻongnon -- 3. Tasanhak kwa mongmin simsŏ -- 4. Sirhak sasang kwa Han sasang -- 5.Kaesin yuhak ŭro pon Hanʼguk chʻŏrhaksa -- 6. Kugyŏk Tasan sasŏ -- 7. Sasang uĭhak kwa saengmyŏng ŭihangnon -- 8. Hanʼguk munhwa ŭi insik, kugyŏkkanyangnok -- 9. Chamnok, susangnok, purok.

In the context of increased movement across borders, this book examines how key cultural texts and concepts are transferred between nations and languages as well as across different media. The texts examined in this book are considered fundamental to their source culture and can also take on a particular relevance to other cultures. The chapters investigate cultural transfers and differences realised through translation and reflect critically upon the implications of these with regard to matters of cultural identity. The book offers (...) an important contribution to cultural approaches in translation studies, with ramifications across different disciplines, including literary studies, history, philosophy, and gender studies. The chapters offer a range of cultural and methodological frameworks and are written by scholars from a variety of language and cultural backgrounds, Western and Eastern. (shrink)

A Hilbert-style version of an implicational logic can be represented by a set of axiom schemes and modus ponens or by the corresponding axioms, modus ponens and substitution. Certain logics, for example the intuitionistic implicational logic, can also be represented by axioms and the rule of condensed detachment, which combines modus ponens with a minimal form of substitution. Such logics, for example intuitionistic implicational logic, are said to be D-complete. For certain weaker logics, the version based on condensed detachment and (...) axioms (the condensed version of the logic) is weaker than the original. In this paper we prove that the relevant logic T→, and any logic of which this is a sublogic, is D-complete. (shrink)